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Why tauroursodeoxycholic acid is better than ursodeoxycholic acid

Tauroursodeoxycholic acid is known as a new generation of bile acid drugs or as a third generation bile acid drug and is commonly used in ursodeoxycholic acid in chemistry.Structure, onset speed, drug metabolism, effectiveness and safety are somewhat different, showing more advantages, as follows:

1.Taurus ursodeoxycholic acid is a new compound. It is a new substance produced by a combination of a multi-step chemical reaction and taurine based on ursodeoxycholic acid. Their chemical structure and physicochemical properties.

There are significant differences.

Structure of ursodeoxycholic acid

Structure of Tauroursodeoxycholic acid

The Tauroursodeoxycholic acid molecular side chain has more polar group taurine groups than ursodeoxycholic acid. The ursodeoxycholic acid is a naturally occurring binding bile acid in human body, which is physiologically active and more Hydrophilic. More soluble in water.The presence of side chain taurine groups has a protective effect, which results in less biotransformation of ursodeoxycholic acid than ursodeoxycholic acid, which is also absorbed in a different manner than ursodeoxycholic acid.

Tauroursodeoxycholic acid buy directly exerts physiological effects.

Studies have shown that ursodeoxycholic acid requires a combination of amidation and taurine to exert physiological effects more effectively. Tauroursodeoxycholic acid is a combination of bile acids that can act directly.Play a pharmacological role, clinically, Tauroursodeoxycholic acid can treat cholesterol stones, effectively cross, the efficiency of dissolved stone is higher.

3. Tauroursodeoxycholic acid is more hydrophilic, can better hydrolyze the bile acid pool, and reduce the toxicity of hydrophobic bile acids in bile.

4. Tauroursodeoxycholic acid has a higher bioavailability than ursodeoxycholic acid, and non-conjugated bile acids such as ursodeoxycholic acid are mainly absorbed in a passive manner.That is, passive absorption of the upper part of the small intestine due to diffusion of the difference in concentration. The bound bile acids are primarily absorbed by the active transport of transporters at the terminal ileum.The absorption efficiency of active transport is much higher than the absorption efficiency of passive diffusion. Secondly, the conversion rate ofTauroursodeoxycholic acid is low, so its bioavailability is high.

Tauroursodeoxycholic acid is safer than ursodeoxycholic acid. Toxicological studies using rats and mice have shown a semi-lethal dose of Tauroursodeoxycholic acid It is about 10 times that of ursodeoxycholic acid.

6. Tauroursodeoxycholic acid is ingested faster than ursodeoxycholic acid, transporting and excreting quickly.

TheTauroursodeoxycholic acid and ursodeoxycholic acid mainly enter the intestinal hepatic circulation, exerting pharmacological effects on the quality of hepatobiliary diseases, and taurours deoxycholic acid can be more effective.Absorbed by the intestines, stem cells are absorbed faster, transported and excreted. The maximum intrahepatic transport and bile secretion rate of Tauroursodeoxycholic acid is 7 times that of ursodeoxycholic acid.

Therefore, Buy tauroursodeoxycholic acid is a new generation of bile acid drugs, which has more advantages and has higher clinical application value.

The protective effect of TUDCA on liver!

Bulk buy tudca at www.scbochem.com!

TUDCA is a new generation of active substance to dissolve cholesterol stone. Studies in recent years have shown that it also has a variety of physiological functions such as protecting liver cells, lowering yellow, lowering enzyme, immunoregulation and inhibiting apoptosis of liver cells.

Camparing to UDCA ,TUDCA is highly ionized and hydrophilic, and has high bioavailability in the intestinal liver circulation, strong liver uptake capacity, and more bile acids, can promote bile excretion, but have little damage to cells and strong cholagogue and liver protection. Recent studies on patients after liver transplantation showed that, after the application of TUDCA, liver cell enzymes (ALT, AST, GGT, ALP) were significantly decreased, and total bile acid was significantly decreased in 5 and 9 months after the addition of TUDCA. In addition, it has good application prospect for fatty liver, cirrhosis and liver cancer.

TUDCA and UDCA is a process which can effectively inhibit the synthesis of liver cholesterol and promoting cholesterol in the form of liquid crystal compounds cholesterol from the gallbladder to intestinal excretion and reduce fat in the liver savings within the organization, enhance the biological activities of catalase, increase the detoxification function of liver tissue, but also significantly reduce the levels of serum triglycerides.

In addition, TUDCA may delay the progression of cirrhosis by inhibiting the expression of TGF- expression 1. 48 cases of cirrhosis were randomly divided into TUDCA group and UDCA group. After 3 months of treatment, the total bile acid and liver cell enzyme of the two groups were significantly decreased and the mean value of serum albumin was significantly increased (P<0.05). At 6 months of treatment, the mean values of serum bilirubin, ALT, AST, ALP and GGT in TUDCA group decreased by 13.7%, 42.8%, 45.9%, 38.4% and 47.7%, respectively, and the mean values of serum albumin were increased by 16.8%, among which serum AST, ALP, GGT and albumin were significantly improved (P<0.05). Serum ALT, GGT and albumin levels were significantly improved in UDCA group (P<0.05). At the end of treatment, ALP and AST decreased significantly in the experimental group compared with the control group (P<0.05). Therefore, TUDCA can improve the liver function indicators of patients with cirrhosis, especially the level of cholestasis, and may delay the progression of liver fibrosis in patients.

Liver cancer is a kind of cancer induced by chronic inflammation. Studies show that inflammatory signal plays a decisive role in the occurrence and development of liver cancer. One feature of liver cancer is the accumulation of non-folding proteins in the endoplasmic reticulum (ER), which leads to non-folding protein reactions (UPR). Endoplasmic reticulum (ER) is an important organelle needed for cell survival. Highly sensitive to changes in the internal balance of cells, disrupted ER balance will lead to accumulation of unfolded proteins, thus interfering with ER function and causing ER stress. TUDCA has been proved to play a protective role of cells by reducing oxidative stress in different models, and ER stress is closely related to oxidative stress. Other studies have shown that TUDCA can eliminate the caspase-12 apoptosis process caused by ER stress and inhibit the activation and apoptosis of the apoptosis-3/7 related factors. TUDCA can also reduce the hepatotoxicity induced by carcinogens, and at least partially alleviate the positive feedback, inflammatory response and apoptosis of endoplasmic reticulum stress in liver tissues damaged by carcinogens, thus preventing the generation of hepatocellular tumors.

How do tudca is produced!

Tudca can be natually found in bear gall,but this is very rare and costly.So Tauroursodeoxycholic acid was developed by Bruschettini S. r of Italy at very the first time.With the development of pharmaceutical preparation technology,tudca can be easily gained from chemical synthesis.

The main raw materials to produce tudca is udca, it is kind of combined bile acid comes from reactant of udca and the amino of taurine. Udca is also by synthesis of animal bile acids such as chenodeoxycholic acid is the most used one.This means tudca prepared in this way inevitably contains a certain amount of Taurochenodeoxycholic acid. CHP request udca has been controlled content of chenodeoxycholic acid and lithocholic acid which will bring tudca Chenodeoxycholic Acid and taurolithocholic acid.The two content of tudca are important test indicators ot its quality and purity.

Next time,we will see the impurity of Tudca.

Welcome to tudca.blogspot.com!

Frist I want to thank you google to provide a free place which we could promoteour business here.I am the owner of ShengChuan Biochem Co.,Ltd which is a ingredients supplier.I am here to promote one of potential and beneficial liver supplement ingredient Tudca (Tauroursodeoxycholic acid).

Tauroursodeoxycholic acid (TUDCA) is an ambiphilic bile acid. It is the taurine conjugate form of ursodeoxycholic acid (UDCA). Humans are found to have trace amounts of TUDCA. However, bears contain large amounts of TUDCA in their bile; UDCA and conjugates comprise about 47% of the bile in American black bears and up to 76% in Asiatic bears.TUDCA has been used in ancient Asian pharmacopoeias for its supposed beneficial effects. UDCA is produced in several countries for the treatment of gallstones and liver cirrhosis. It is not approved by the Food and Drug Administration, in the U.S. while UDCA is approved in the United States for the treatment of primary biliary cirrhosis Ongoing research is finding TUDCA has diminishing apoptotic effects, helping with cardiac function, Huntington's disease, Parkinson's disease, and stroke.Recently, TUDCA has been found to have protective effects in the eye, especially concerning retinal degenerative disorders.

The clinic study has showed lots of benifits we can get from tudca as below:
1) TUDCA Decreases Elevated Liver Enzymes
2) TUDCA Helps Treat Cholestasis
3) TUDCA Combats Liver Cirrhosis
4) TUDCA Helps Treat Hepatitis
5) TUDCA Increases Insulin Sensitivity
6) TUDCA Helps Treat Complications of Diabetes
7) TUDCA May Help Treat Alzheimer’s Disease
8) TUDCA May Help Treat Parkinson’s Disease
9) TUDCA May Help Treat Huntington’s Disease
11) TUDCA Protects Against Strokes
12) TUDCA Reduces Damage From Heart Attack
13) TUDCA May Improve Retinal Health

So much benifits tudca bring to our liver and body,it is really a potential new ingredient we should let more people know about it.
Buy GMP certified Tudca at www.scbiochem.com.